Melanoma of the Skin Procedure Type: Biopsy, shave Biopsy, punch Biopsy, incisional Excision Re-excision Lymphadenectomy, sentinel node(s) Lymphadenectomy, regional nodes (specify): Other (specify): Not specified Specimen Laterality: Right Left Midline Not specified Tumor Site: Specify (if known): Not specified Tumor Size (required only if tumor is grossly present): Greatest dimension (cm): Additional dimensions (cm): Indeterminate: Macroscopic Satellite Nodule(s) (required for excision specimens only): Not identified Present Indeterminate Macroscopic Pigmentation: Not identified Present, diffuse Present, patchy/focal Indeterminate Histologic Type: Malignant melanoma: Melanoma, not otherwise classified Superficial spreading melanoma Nodular melanoma Lentigo maligna melanoma Acral-lentiginous melanoma Desmoplastic and/or desmoplastic neurotropic melanoma Melanoma arising from blue nevus Melanoma arising in a giant congenital nevus Melanoma of childhood Nevoid melanoma Persistent melanoma Other (specify): Maximum Tumor Thickness: Specify: mm At least mm () Indeterminate () Anatomic Level: I (Melanoma in situ) II (Melanoma present in but does not fill and expand papillary dermis) III (Melanoma fills and expands papillary dermis) IV (Melanoma invades reticular dermis) V (Melanoma invades subcutaneum) Ulceration: Present Not identified Indeterminate Margins: Peripheral Margins: Cannot be assessed Uninvolved by invasive melanoma, distance of invasive melanoma from closest peripheral margin: mm at (required for excisions only) Involved by invasive melanoma at Uninvolved by melanoma in situ, distance of melanoma in situ from closest margin: mm at (required for excisions only) Involved by melanoma in situ at Deep Margin: Cannot be assessed Uninvolved by invasive melanoma, distance of invasive melanoma from margin: mm at (required for excisions only) Involved by invasive melanoma at Mitotic Index: Less than 1 / mm2 Specify number / mm2 Other: Microsatellitosis: Not identified Present Indeterminate Lymph-Vascular Invasion: Not identified Present Indeterminate Perineural Invasion: Not identified Present Indeterminate Tumor-Infiltrating Lymphocytes: Not identified Present, nonbrisk Present, brisk Tumor Regression: Not identified Present, involving less than 75% of lesion Present, involving 75% or more of lesion Indeterminate Growth Phase: Radial Vertical Indeterminate Lymph Nodes (required only if lymph nodes are present in the specimen) : Number of sentinel nodes examined: Total number of nodes examined (sentinel and nonsentinel): Number of lymph nodes with metastases: Extranodal tumor extension: Present Not identified Indeterminate Size of largest metastatic focus (mm): (for sentinel node) Location of metastatic tumor (for sentinel node): Subcapsular Intramedullary Subcapsular and intramedullary Pathologic Staging (pTNM) TNM Descriptors (required only if applicable) m (multiple) r (recurrent) y (posttreatment) Primary Tumor (pT): pTX: Primary tumor cannot be assessed (eg, shave biopsy or regessed melanoma): pT0: No evidence of primary tumor pTis: Melanoma in situ (ie, not an invasive tumor: anatomic level I) pT1: Melanoma 1.0 mm or less in thickness, with or without ulceration pT1a: Melanoma 1.0 mm or less in thickness, no ulceration, <1 mitoses/mm2 pT1b: Melanoma 1.0 mm or less in thickness with ulceration and/or 1 or more mitoses/mm2 pT2: Melanoma 1.01 to 2 mm in thickness, with or without ulceration pT2a: Melanoma 1.01 to 2.0 mm in thickness, no ulceration pT2b: Melanoma 1.01 to 2.0 mm in thickness, with ulceration pT3: Melanoma 2.01 to 4.0 mm in thickness, with or without ulceration pT3a: Melanoma 2.01 to 4.0 mm in thickness, no ulceration pT3b: Melanoma 2.01 to 4.0 mm in thickness, with ulceration pT4: Melanoma greater than 4.0 mm in thickness, with or without ulceration pT4a: Melanoma greater than 4.0 mm in thickness, no ulceration pT4b: Melanoma greater than 4.0 mm in thickness, with ulceration Regional Lymph Nodes (pN): pNX: Regional lymph nodes cannot be assessed pN0: No regional lymph node metastasis pN1: Metastasis in 1 regional lymph node: pN1a: Clinically occult (microscopic) metastasis pN1b: Clinically apparent (macroscopic) metastasis pN2: Metastasis in 2 to 3 regional nodes or intralymphatic regional metastasis without nodal metastasis: pN2a: Clinically occult (microscopic) metastasis pN2b: Clinically apparent (macroscopic) metastasis pN2c: Satellite or in-transit metastasis without nodal metastasis pN3: Metastasis in 4 or more regional lymph nodes, or matted metastatic nodes, or in-transit metastasis or satellites(s) with metastasis in regional node(s) Number of lymph nodes identified: Number containing metastases identified macroscopically: Number containing metastases identified microscopically: Matted nodes: Present Not identified Distant Metastasis (pM): Not applicable pM1: Distant metastasis (documented in this specimen) pM1a: Metastasis in skin, subcutaneous tissues, or distant lymph nodes pM1b: Metastasis to lung pM1c: Metastasis to all other visceral sites or distant metastasis at any site associated with an elevated serum lactic dehydrogenase (LDH): Specify site, if knownAdditional Pathologic Findings: Nevus remnant Other (specify): Comment(s):