Specimen:
Larynx, supraglottis
Larynx, glottis
Larynx, subglottis
Other (specify):
Not specified

Received:
Fresh
In formalin
Other (specify):

Procedure Type:
   Incisional biopsy
   Excisional biopsy
   Resection:
       Stripping (glottis)
       Transoral laser excision (glottis)
       Supraglottic laryngectomy
       Supracricoid laryngectomy
       Vertical hemilaryngectomy (specify side):
       Partial laryngectomy (specify type):
       Total laryngectomy
   Neck (lymph node) dissection (specify):
   Other (specify):
   Not specified

Specimen Integrity:
    Intact
    Fragmented

Laryngectomy:
Open
Unopened

Specimen Size:
Greatest dimensions (cm):

Additional dimensions (if more than one part) (cm):

Tumor Laterality:
   Right
   Left
   Bilateral; Transglottic:
    Yes
    No
   Midline
   Not specified

Tumor Site:
   Larynx, supraglottis:
       Epiglottis
       Lingual aspect
       Laryngeal aspect
       Aryepiglottic folds
       Arytenoid(s)
       False vocal cord
       Ventricle
   Larynx, glottis:
       True vocal cord
       Anterior commissure
       Posterior commissure
   Larynx, subglottis
   Other (specify):
   Not specified

Tumor Focality:
Single focus
Bilateral
Multifocal (specify):

Tumor Size:
   Greatest dimension (cm):
   Additional dimensions: x cm
   Cannot be determined (see Comment)

Tumor Description:
Gross subtype:
Polypoid
Exophytic
Endophytic
Ulcerated
Sessile
Other (specify):

Macroscopic Extent of Tumor:

Histologic Type:
Squamous cell carcinoma, conventional
Variants of Squamous Cell Carcinoma:
    Acantholytic squamous cell carcinoma
    Adenosquamous carcinoma
    Basaloid squamous cell carcinoma
    Papillary squamous cell carcinoma
    Spindle cell squamous cell carcinoma
    Verrucous carcinoma
Giant cell carcinoma
Lymphoepithelial carcinoma (non-nasopharyngeal)
Neuroendocrine Carcinoma:
    Typical carcinoid tumor (well differentiated neuroendocrine carcinoma)
    Atypical carcinoid tumor (moderately differentiated neuroendocrine carcinoma)
    Small cell carcinoma, neuroendocrine type (poorly differentiated neuroendocrine carcinoma)
    Combined (or composite) small cell carcinoma, neuroendocrine type
Mucosal malignant melanoma
Carcinomas of Minor Salivary Glands:
    Adenoid cystic carcinoma
    Mucoepidermoid carcinoma:
        Low grade
        Intermediate grade
        High grade
    Other (specify):
Other carcinoma (specify):
Carcinoma, type cannot be determined

Histologic Grade:
Not applicable
GX: Cannot be assessed
G1: Well differentiated
G2: Moderately differentiated
G3: Poorly differentiated
Other (specify):

Microscopic Tumor Extension:

Margins:
   Cannot be assessed
   Margins uninvolved by invasive carcinoma, distance from closest margin: at
   Margins involved by invasive carcinoma:
   Margins uninvolved by carcinoma in situ (includes moderate and severe dysplasia), distance from closest margin: at
   Margins involved by carcinoma in situ (includes moderate and severe dysplasia):
   Not applicable

Treatment Effect:
    Not identified
    Present (specify):
    Indeterminate

Lymph-Vascular Invasion:
Not identified
Present
Indeterminate

Perineural Invasion:
Not identified
Present
Indeterminate

Lymph Nodes, Extranodal Extension:
Not identified
Present
Indeterminate

Pathologic Staging (pTNM):

TNM Descriptors
m (multiple primary tumors)
r (recurrent)
y (post-treatment)



Primary Tumor (pT):
pTX: Cannot be assessed
pT0: No evidence of primary tumor
pTis: Carcinoma in situ
Supraglottis:
    pT1: Tumor limited to one subsite of supraglottis with normal vocal cord mobility
    pT2: Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (eg, mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx
    pT3: Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage
    pT4a: Moderately advanced local disease. Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, soft tissues of neck including deep extrinsic muscle of tongue, strap muscles, thyroid, or esophagus)
    pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures
Glottis:
    pT1: Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility
    pT1a: Tumor limited to one vocal cord
    pT1b: Tumor involves both vocal cords
    pT2: Tumor extends to supraglottis and/or subglottis and/or with impaired vocal cord mobility
    pT3: Tumor limited to the larynx with vocal cord fixation and/or invades paraglottic space and/or minor thyroid cartilage erosion (eg, inner cortex) (Note H)
    pT4a: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus) (Note H)
    pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures
Subglottis:
    pT1: Tumor limited to subglottis
    pT2: Tumor extends to vocal cord(s) with normal or impaired mobility
    pT3: Tumor limited to larynx with vocal cord fixation
    pT4a: Moderately advanced local disease. Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus)
    pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures
Mucosal Malignant Melanoma:
    pT3: Mucosal disease
    pT4a: Moderately advanced disease. Tumor involving deep soft tissue, cartilage, bone, or overlying skin
    pT4b: Very advanced disease. Tumor involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures

Regional Lymph Nodes (pN):
Not Mucosal Malignant Melanoma

    pNX: Cannot be assessed
    pN0: No regional lymph node metastasis ( 0 / )
    pN1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension ( 1 / )
    pN2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension ( 1 / )
    pN2a: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension ( 1 / )
    pN2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension ( / )
    pN2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension ( / )
    pN3: Metastasis in a lymph node more than 6 cm in greatest dimension ( / )
Mucosal Malignant Melanoma

    pNX: Regional lymph nodes cannot be assessed
    pN0: No regional lymph node metastases
    pN1: Regional lymph node metastases present

Size (greatest dimension) of the largest positive lymph node (cm):

Superior mediastinal lymph nodes are considered regional lymph nodes (level VII). Midline nodes are considered ipsilateral nodes.

Distant Metastasis (pM):
Not applicable
pM1: Distant metastasis at Specify site(s), if known, and source of pathologic metastatic specimen

Additional Pathologic Findings:
   None identified
   Keratinizing dysplasia:
    Mild
    Moderate
    Severe (carcinoma in situ)
   Non-keratinizing dysplasia:
    Mild
    Moderate
    Severe (carcinoma in situ)
   Inflammation (specify type):
   Squamous metaplasia
   Epithelial hyperplasia
   Colonization:
    Fungal
    Bacterial
   Other (specify):

Ancillary Studies:

Treatment History:
       Neoadjuvant therapy:
        Yes (specify type):
        No
        Indeterminate
       Other (specify):

Comments: